Brain Imaging
How to Participate

Down Syndrome

It has been recently recognized that individuals with Down syndrome are at increased risk for developing dementia and changes in the brain associated with Alzheimer disease. Specifically, amyloid, the protein found in the brain of individuals with Alzheimer disease, has been also found to be present in adults with Down syndrome.  More details regarding Alzheimer disease in individuals in Down syndrome can be found under our description of Neurologic Conditions.  The table below lists  the imaging studies currently being conducted for adults with Down syndrome.

Type of Study

Study Description


Amyloid imaging in adults with Down Syndrome

The life expectancy of people with Down syndrome has dramatically improved over the decades. However aging is accelerated and Alzheimer disease is commonly seen after the age of 40.   Brain imaging is being developed for early detection of Alzheimer disease and to help better understand changes in thinking that occur in Down Syndrome with age

Currently enrolling

FDG imaging in  adults with Down Syndrome

FDG PET (link to section 3B), the most widely available PET tracer, provides measures of regional brain glucose metabolism. FDG PET scans may help detect changes in the brain metabolism in individuals with changes in their thinking or function that may represent Alzheimer disease.  FDG PET may help to differentiate Alzheimer disease from other forms of cognitive changes in individuals with Down syndrome.

Currently enrolling


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